Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments

Figure 2 Simplified representation of the thiopurine metabolism. Azathioprine is non-enzymatically converted to 6-mercaptopurine, which is competitively converted into 6-methymercaptopurine, 6-thiouric acid and 6-thiosine 5’-monophosphate by different enzymes. The latter metabolite is further transformed into the metabolic active 6-thioguanine nucleotides.