Human liver chimeric mouse model based on diphtheria toxin-induced liver injury

Figure 1 Experimental design and PCR analysis of Alb-cre/diphtheria toxin receptor transgenic mice. A: Experimental design used to characterize DT liver injury in ADSB mice, which were used for human hepatocyte transplantation; B: PCR analysis of the Alb-cre gene, Tg1, Tg2 and Tg4 mice are cre-positive; C: PCR analysis of the DTR gene, Tg1, Tg2 and Tg5 are homozygous DTR mice, and Tg3 and Tg4 are heterozygous DTR mice. ADSB: Triple-crossed albumin (Alb)-cre transgenic mice, inducible diphtheria toxin receptor (DTR) transgenic mice and severe combined immune deficient-beige mice; DT: Diphtheria toxin.