miR-29a promotes hepatitis B virus replication and expression by targeting SMARCE1 in hepatoma carcinoma

Figure 6 miR-29a promotes hepatitis B virus replication and expression by targeted regulation of SMARCE1 (n = 3). HepG2.2.15 cells were transfected with miR-control or miR-29a mimics or co-transfected miR-29a mimics with pcDNA-control or pcDNA-SMARCE1. A and B: Restored expression of SMARCE1 by pcDNA-SMARCE1 relieved the increased HBV replication by miR-29a overexpression; C and D: Restored expression of SMARCE1 by pcDNA-SMARCE1 reversed the increased HBsAg and HBeAg expression by miR-29a overexpression. Data represent the mean ± SD. ^aP < 0.05, vs miR-control. HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; RC: Relaxed circular; SS: Single-stranded.