Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice

Table 3 Effects of Liuwei Dihuang Pill on body weights and serum biochemical parameters

Group	Body weights at week 20, g	Body weights at week 30, g	ALT, U/L	AST, U/L	BUN, mmol/L	Cr, μmol/L
db/m + MNU + saline	24.80 ± 1.08	25.56 ± 1.78	8.98 ± 1.78e	8.91 ± 1.45	4.80 ± 0.26	13.94 ± 4.17
db/db + MNU + saline	59.22 ± 5.61	61.18 ± 2.10	53.31 ± 8.31	10.23 ± 0.90	4.65 ± 0.52	18.44 ± 6.28
db/db + MNU + metformin	59.44 ± 3.38	48.90 ± 4.99b	23.40 ± 2.37b	10.79 ± 1.52	4.64 ± 0.51	9.45 ± 3.07
db/db + MNU + LDP	62.79 ± 5.03	57.96 ± 3.34	38.08 ± 4.81a	11.30 ± 1.14	4.85 ± 0.45	9.00 ± 1.50

Data are presented as mean ± SE.

^aP < 0.05,

^bP < 0.01,

^eP < 0.001 vs db/db + MNU + saline group by one-way ANOVA. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LDP: Liuwei Dihuang Pill; MNU: N-methyl-N-nitrosourea.