Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

Figure 2 Perspective view of the resected specimen. A: Variably sized glands are diffusely dispersed accompanying stromal fibrosis in the mucosal and submucosal layers. In the deepest zone, some solid nests without a luminal structure are evident; B: Invasive carcinoma is composed of round or oval-shaped glands and irregularly dilated glands; C: Invasive tumor nests of keratinizing squamous cell carcinoma are observed in the deepest part of the lesion; D: A higher-power view shows that the glands are have two cell layers. Most cells do not exhibit enough atypia to support a diagnosis of dysplasia; E: The underlying carcinoma component is focally continuous with the surface covering epithelial layer. Although the covering epithelium is obviously thinned compared with surrounding epithelium, we found no significant atypia in the area continuous with the invasive carcinoma. B and E: Magnification 100 ×; C and D Magnification 200 ×.