Cautiously using natural medicine to treat liver problems

Table 3 Information of some natural plants for treatment of liver problems

Natural plants	Ref.	Literature type	Effects and mechanisms/possible mechanisms	Adverse reactions
Coffee	Masterton et al[10], 2010	Review	Potential to reduce risk of abnormal liver function tests, cirrhosis and hepatocellular carcinoma	Clinical dependency, withdrawal,
				tolerance or intoxication
	Wadhawan et al[33], 2016	Review	Reducing incidence of fibrosis and cirrhosis, hepatocellular carcinoma rates, and decreasing mortality	Not mentioned
Apple	Codoñer-Franch et al[34], 2013	Article	Protective action against oxidative stress induced by tamoxifen in rats	Not mentioned
	Sharma et al[35], 2016	Article	Antioxidant activity; able to induce protein expression of nuclear factor (erythroid-derived 2)-like 2 to inhibit CCl4-induced apoptosis	Not mentioned
Resveratrol	Burns et al[38], 2002	Review	anti-oxidative, anti-carcinogenic, and antitumor properties	Not mentioned
	Andrade et al[39], 2014	Article	Improving lipid metabolism, decreasing incidence of nonalcoholic fatty liver disease, pro-inflammatory profile in liver of mice fed with obesity-inducible diets	Not mentioned