Clinical Trials Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Apr 21, 2017; 23(15): 2771-2784
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2771
Table 5 Urinary metabolites differentially expressed in patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
No.MetabolitesVIP-value (OPLS-DA)P value (t-test)Fold change
ESI+
1L-Carnitine1.2530.067-0.727
2L-Dopa0.9520.0920.234
3Acetylcarnitine1.1810.094-0.698
4L-Histidine1.2290.081-1.339
5Pyroglutamic acid1.5410.0210.143
63-Methylxanthine2.4030.002-1.981
7α-D-Glucose1.7390.013-1.376
85-Hydroxyferulate0.8950.058-0.266
92-Oxosuberate0.8500.073-0.315
10p-Hydroxyphenylacetic acid1.3540.0950.398
113-Indoleacetic Acid0.9150.052-0.378
12β-Estradiol1.8830.002-0.635
13Phosphorylcholine1.7310.0320.716
1417α-Hydroxypregnenolone0.8540.087-0.281
15Deoxycorticosterone0.8650.093-0.312
16Progesterone0.8660.084-0.301
ESI-
172-Keto-glutaramic acid1.6530.0270.210
18cAMP1.6590.0410.196
197-Methylxanthine1.5950.036-0.925
20(S)-(-)-2-Hydroxyisocaproic acid1.3440.089-0.250
21Gluconic acid1.6380.025-1.111
22N-Acetylproline1.8650.0210.399
23Acetyl-DL-valine1.6360.0530.284
24Pyridoxal phosphate1.4900.050-0.990
25N-Acetyl-DL-tryptophan1.4400.059-0.951
262-Keto-D-gluconic acid1.2580.088-0.340
27D-(+)-3-Phenyllactic acid2.0210.017-1.621
28Indoleactic acid1.4950.0510.832
293-Hydroxy-sebacic acid1.2700.092-0.292
30Sebacic acid1.8470.0240.420
31Deoxyguanosine1.548