Colorectal and interval cancers of the Colorectal Cancer Screening Program in the Basque Country (Spain)

Table 1 Characteristic of interval cancers and screen-detected colorectal cancers n (%)

	Interval cancers		Screen-detected (SCs)	P value
	FIT	Post-colonoscopy
Total	186 (6.8)	18 (0.7)	2518 (92.5)	-
Patient characteristics
Sex
Male	125 (67.2)	10 (55.6)	1651 (65.6)	0.601
Female	61 (32.8)	8 (44.4)	867 (34.4)
Age (yr)
Mean (SC)	60.2 (4.9)	62.0 (3.5)	61.7 (3.4)	0.042
50-54	28 (15.1)	0 (0)	375 (14.9)
55-59	53 (28.5)	5 (27.8)	539 (21.4)	0.001
60-64	61 (32.8)	10 (55.6)	709 (28.2)
65-69	44 (23.7)	3 (16.7)	895 (35.5)
Round of invitation				0.001
1	143 (76.9)	16 (88.9)	1615 (64.1)
2	40 (21.5)	2 (11.1)	680 (27.0)
3	3 (1.6)	0 (0)	223 (8.9)
Type participation				0.086
Initial	149 (80.1)	17 (94.4)	1863 (74.0)
Regular	35 (18.8)	1 (5.6)	639 (25.4)
Irregular	2 (1.1)	0 (0)	16 (0.6)
Deprivation Index				0.192
1 (least deprived)	42 (23.9)	3 (16.7)	521 (21.4)
2	43 (24.4)	1 (5.5)	503 (20.6)
3	29 (16.5)	6 (33.4)	539 (22.1)
4	38 (21.6)	2 (11.1)	461 (18.9)
5 (most deprived)	24 (13.6)	5 (27.8)	414 (17.0)
Unknown	0 (0)	1 (5.5)	0 (0)
Time to diagnosis (months)			-	< 0.0001
Median (IQR)	13.5 (8.5-18.9)	28.1 (16.5-40.1)
Range	1.5-39.4	5.6-61.2
Cancer characteristics
Location				< 0.0001
Proximal1	68 (36.6)	7 (38.9)	478 (19.0)
Distal2	58 (31.2)	9 (50.0)	1529 (60.7)
Rectum	58 (31.2)	2 (11.1)	404 (16.0)
Unknown	2 (1.1)	0 (0)	107 (4.2)
Stage				< 0.0001
I	43 (23.1)	4 (22.2)	1376 (54.6)
II	36 (19.4)	2 (11.1)	408 (16.2)
III	57 (30.6)	7 (38.9)	566 (22.5)
IV	50 (26.9)	5 (27.8)	152 (6.0)
Unknown	0 (0)	0 (0)	16 (0.6)
Morphology				0.002
ADC, NOS	139 (74.7)	15 (83.3)	1823 (72.4)
ADC in adenomatous polyp	4 (2.2)	0 (0)	121 (4.8)
Carcinoid tumor	0 (0)	0 (0)	7 (0.3)
ADC in villous adenoma	6 (3.2)	0 (0)	154 (6.1)
ADC in tubulovillous adenoma	10 (5.4)	0 (0)	174 (6.9)
Mucinous ADC	5 (2.7)	2 (11.1)	42 (1.7)
Mucin-producing ADC	3 (1.6)	0 (0)	23 (0.9)
Signet ring cell carcinoma	0 (0)	0 (0)	4 (0.2)
Other	15 (8.1)	0 (0)	64 (2.5)
Unknown	4 (2.2)	1 (5.6)	106 (4.2)
Degree of differentiation				< 0.0001
Well differentiated	76 (41.1)	7 (38.9)	988 (39.2)
Moderately differentiated	59 (31.9)	7 (38.9)	1061 (42.2)
Poorly differentiated	14 (7.6)	1 (5.5)	86 (3.4)
Undifferentiated/anaplastic	33 (17.8)	2 (11.1)	320 (12.7)
Unknown	3 (1.6)	1 (5.5)	63 (2.5)
Size (mm)				0.022
Median (IQR)	20 (8.0-40.0)	38.0 (30.0-60.0)	26.0 (19.7-40.0)
Range	2.0-90.0	9.0-80.0	2.0-95.0
Treatment				< 0.0001
Endoscopic resection	5 (2.7)	0 (0)	733 (29.1)
Surgery	56 (30.1)	9 (50.0)	182 (7.2)
Surgery and neoadjuvant therapy	106 (57.0)	7 (38.9)	1332 (52.9)
Palliative procedure	18 (9.7)	2 (11.1)	164 (6.6)
Unknown	1 (0.5)	0 (0)	107 (4.2)

¹Cecum, Ascending, Hepatic Flexure, and Transverse;

²Splenic Flexure, Descending, Sigmoid. ADC: Adenocarcinoma; FIT: Faecal inmunochemical test.