Clinical implication of FDG uptake of bone marrow on PET/CT in gastric cancer patients with surgical resection

Table 5 Multivariate analysis of prognostic factors for recurrence-free survival and overall survival in model with all 309 patients and 156 patients with positive F-18 fluorodexoyglucose uptake

Variables	Model with all patients		Model with patients with positive FDG uptake
	P value	HR (95%CI)	P value	HR (95%CI)
RFS
Age	0.461	1.38 (0.58-3.28)	0.228	1.69 (0.72-3.96)
Location
Body		1.00		1.00
Fundus	0.543	0.50 (0.05-4.78)	0.634	0.58 (0.06-5.32)
Antrum	0.276	0.64 (0.29-1.42)	0.695	0.86 (0.41-1.82)
Multiple	0.037	6.06 (1.36-26.92)	0.034	5.19 (1.13-23.76)
T stage
T1		1.00		1.00
T2	0.342	1.81 (0.53-6.19)	0.250	2.05 (0.60-6.99)
T3	0.200	2.31 (0.64-8.29)	0.096	3.01 (0.82-10.97)
T4	0.020	4.99 (1.29-19.38)	0.014	5.50 (1.42-21.31)
Lymph node metastasis	0.037	2.96 (1.07-8.21)	0.004	4.50 (1.61-12.54)
Tumor size	0.661	1.27 (0.43-3.75)	0.594	1.34 (0.46-3.95)
Tumor involvement of resection margin	0.035	4.32 (1.11-16.81)	0.023	4.94 (1.24-19.62)
White blood cell	0.150	1.96 (0.78-4.92)	0.053	2.37 (0.99-5.67)
Hemoglobin	0.652	1.24 (0.49-3.11)	0.955	0.97 (0.38-2.50)
NLR	0.611	1.25 (0.53-2.90)	0.607	1.24 (0.54-2.86)
PLR	0.563	1.30 (0.53-3.18)	0.197	1.78 (0.74-4.27)
Albumin	0.060	0.42 (0.17-1.04)	0.021	0.34 (0.14-0.85)
CRP	0.173	1.88 (0.76-4.68)	0.181	1.85 (0.75-4.55)
FDG uptake	0.058	2.72 (0.97-7.65)
Tmax			0.215	1.33 (0.70-2.39)
BM SUV	0.945	0.94 (0.38-2.33)	0.597	0.80 (0.34-1.86)
BLR	0.001	6.42 (2.07-19.84)	0.005	7.67 (2.44-24.12)
OS
T stage
T1		1.00		1.00
T2	0.994	1.01 (0.13-8.41)	0.965	1.93 (0.29-13.05)
T3	0.537	1.78 (0.28-11.15)	0.500	1.93 (0.29-13.05)
T4	0.002	5.33 (1.88-15.14)	< 0.001	6.15 (2.18-17.34)
Lymph node metastasis	0.016	5.08 (1.36-18.94)	0.092	3.40 (0.82-14.11)
Tumor size	0.243	3.62 (0.42-31.35)	0.242	3.77 (0.41-34.80)
Tumor involvement of resection margin	0.194	3.16 (0.56-17.93)	0.209	3.13 (0.53-18.54)
Hemoglobin	0.026	0.32 (0.11-0.87)	0.463	0.46 (0.14-1.57)
PLR	0.741	0.82 (0.25-2.66)	0.896	0.92 (0.29-2.99)
Albumin	0.759	0.84 (0.27-2.61)	0.675	0.78 (0.24-2.52)
FDG uptake	0.197	4.29 (0.47-39.12)
Tmax			0.059	2.89 (0.96-8.72)
BLR	0.025	10.39 (1.34-80.33)	0.022	10.87 (1.42-83.31)

FDG: F-18 fluorodexoyglucose; RFS: Recurrence-free survival; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CRP: C-reactive protein; PET/CT: Positron emission tomography/computed tomography; BM: Bone marrow; BLR: BM-to-liver uptake ratio.