Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer

Table 2 Relationships between different CRM1 and CDK5 protein expression status in gastric cancer tissues and various clinicopathological variables

Variables	Total	CRM1 and CDK5 High expression	CRM1 or CDK5 Low expression	CRM1 and CDK5 Low expression	χ2	P value
Gender
Male	178	42	87	49	2.553	0.279
Female	62	21	27	14
Age at surgery(yr)
≤ 60	120	35	54	31	1.109	0.574
> 60	120	28	60	32
Size of primary tumor (cm)
≤ 5	99	22	42	35	7.275	0.0261
> 5	141	41	72	28
Location of primary tumor
Lower 1/3	56	18	19	19	10.848	0.093
Middle 1/3	59	14	32	13
Upper 1/3	103	22	52	29
More than 1/3	22	9	11	2
Borrmann type
Early stage	10	2	5	3	6.035	0.197
I + II type	89	20	38	31
III + IV type	141	41	71	29
Degree of differentiation
Well/moderate	96	18	43	35	10.027	0.0071
Poor and not	144	45	71	28
Lauren’s classification
Intestinal type	46	17	24	5	7.875	0.0191
Diffuse type	194	46	90	58
Histological type
Papillary	7	2	3	2	11.127	0.850
Tubular	187	44	87	56
Mucinous	20	5	13	2
Signet-ring cell	26	12	11	3
Depth of invasion
T1	40	8	17	15	10.996	0.088
T2	27	4	13	10
T3	62	16	27	19
T4	111	35	57	19
Lymph node metastasis
N0	63	15	22	26	15.845	0.0151
N1	40	9	22	9
N2	43	7	26	10
N3	94	32	44	18
TNM stage
I	44	8	17	19	13.543	0.0351
II	55	14	24	17
III	123	33	65	25
IV	18	8	8	2
Vessel invasion
Negative	230	62	105	63	7.757	0.0211
Positive	10	1	9	0
Distant metastasis
Negative	222	55	106	61	4.191	0.123
Positive	18	8	8	2

¹P < 0.05, statistical significance. CRM: Chromosomal maintenance; CDK: Cyclin-dependent kinase.