Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer

Table 1 Relationships between CRM1 and CDK5 protein expression (immunohistochemical staining) in gastric cancer tissues and various clinicopathological variables

Variables	Total	CRM1 expression				CDK5 expression
		Low (n = 149)	High (n = 91)	χ2	P value	Low (n = 91)	High (n = 149)	χ2	P value
Gender
Male	178	110	68	0.024	0.877	61	117	3.893	0.0481
Female	62	39	23			30	32
Age at surgery (yr)
≤ 60	120	78	42	0.867	0.352	46	74	0.018	0.894
> 60	120	71	49			45	75
Size of primary tumor (cm)
≤ 5	99	51	48	7.995	0.0051	35	64	0.470	0.493
> 5	141	98	43			56	85
Location of primary tumor
Upper 1/3	56	33	23	5.290	0.152	22	34	1.718	0.633
Middle 1/3	59	39	20			21	38
Lower 1/3	103	59	44			37	66
More than 1/3	22	18	4			11	11
Borrmann type
Early stage	10	4	6	10.118	0.0061	5	5	0.774	0.679
I + II type	89	46	43			32	57
III + IV type	141	99	42			54	87
Degree of differentiation
Well/moderate	96	49	47	8.287	0.0041	30	66	3.021	0.082
Poor and not	144	100	44			61	83
Lauren’s classification
Intestinal type	46	33	13	2.254	0.176	25	21	6.527	0.0111
Diffuse type	294	116	78			66	128
Histological type
Papillary	7	4	3	2.958	0.398	3	4	7.052	0.070
Tubular	187	112	75			63	124
Mucinous	20	13	7			10	10
Signet-ring cell	26	20	6			15	11
Depth of invasion
T1	40	18	22	11.908	0.0081	15	25	2.145	0.543
T2	27	13	14			8	19
T3	62	38	24			21	41
T4	111	80	31			47	64
Lymph node metastasis
N0	63	29	34	10.781	0.0131	23	40	4.868	0.182
N1	40	29	11			11	29
N2	43	26	17			14	29
N3	94	65	29			43	51
TNM stage
I	44	18	26	15.074	0.0021	15	29	1.058	0.787
II	55	33	22			19	36
III	123	82	41			49	74
IV	18	16	2			8	10
Vessel invasion
Negative	230	141	89	1.423	0.233	88	142	0.278	0.598
Positive	10	8	2			3	7
Distant metastasis
Negative	222	133	89	5.940	0.0151	83	139	0.352	0.553
Positive	18	16	2			8	10

¹P < 0.05, statistical significance. CRM: Chromosomal maintenance; CDK: Cyclin-dependent kinase.