Catheterization of the gallbladder: A novel mouse model of severe acute cholangitis

Figure 3 Relieving biliary obstruction reduces mortality and attenuates liver injury in the severe acute cholangitis mouse model. A: The survival rates of SAC mice with or without biliary drainage were determined at 48 h after model establishment (n = 10); B: ALT, AST, and TBIL of SAC mice with or without biliary drainage were examined at 48 h after model establishment (n = 6). ^aP < 0.05 vs SAC group; ^cP < 0.05, difference between the two groups; C: Histological analysis of liver tissues in mice after different treatments (HE × 200), asterisk: necrosis; D and E: Determination of pro-inflammatory cytokines in serum and bile of patients with or without SAC (n = 6). ^aP < 0.05 vs gallstone group; ^cP < 0.05 vs biliary obstruction group; F: The survival rates of mice which were intraperitoneally injected with high-dose of LPS under the condition of biliary obstruction. BD: Biliary drainage.