Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody

doi:10.3748/wjg.v23.i1.48

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 7, 2017; 23(1): 48-59
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.48

Table 3 Association between cagA genotype and the accuracy of CagA antibody ELISA

Group name	n	Western-type CagA ELISA				East Asian-type CagA ELISA
cagA genotype		(cut off value: 6.25 U/mL)				(cut off value: 45.0 U/mL)
cagA genotype		Sens.	Sp.	AUC	95%CI	Sens.	Sp.	AUC	95%CI
Western and East Asian	110	62.7	97.2	0.87	0.82-0.92	70.9	93.5	0.91	0.86-0.95
Western	38	84.2	97.2	0.92	0.83-0.99	65.8	93.5	0.91	0.86-0.96
East Asian	72	51.4¹	97.2	0.85	0.79-0.91	73.6¹	93.5	0.90	0.85-0.95

¹Statistically significant between Western-type CagA ELISA and East Asian-type CagA ELISA (P < 0.001). n: The number of Helicobacter pylori (H. pylori) infected subjects; 107 H. pylori uninfected subjects were added for ROC analysis. Sens.: Sensitivity; Sp.: Specificity; AUC: Area under the curve.

Citation: Matsuo Y, Kido Y, Akada J, Shiota S, Binh TT, Trang TTH, Dung HDQ, Tung PH, Tri TD, Thuan NPM, Tam LQ, Nam BC, Khien VV, Yamaoka Y. Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody. World J Gastroenterol 2017; 23(1): 48-59
URL: https://www.wjgnet.com/1007-9327/full/v23/i1/48.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i1.48