Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice

Figure 5 Predicted mechanism of hepatic lipid metabolism on methionine-choline-deficient diet-induced nonalcoholic steatohepatitismodel. MCD increases FATP in the liver and hepatic FFA contents are increased. SREBP-1c modulates fatty acid synthase, and facilitates hepatic de novo lipogenesis. Fatty acid synthase produces Acyl-CoA which is catalyzed by ACOX1 in β-oxidation. Accumulated FFA is stored in hepatocytes as TG, and hepatic TG are excreted by MTTP, as VLDL. MCD: Methionine-choline-deficient diet; FATP: Fatty acid transport protein; FFA: Free fatty acid; SREBP-1c: Sterol regulatory element-binding protein-1c; ACOX1: Acyl-coenzyme A oxidase 1; TG: Triglyceride; MTTP: Microsomal triglyceride transfer protein; VLDL: Very low density lipoprotein.