Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing

Table 2 Next-generation sequencing studies of esophageal squamous cell carcinoma to date

Study	Method	Sample number	Number of non-silent mutations/tumor	Additional analyses	Platform
Agrawal et al[31]	WES	12 WES	83	-	GA IIx
Song et al[34]	WGS and WES	17 WGS, 71 WES	61	123 CGH	HiSeq 2000
Lin et al[33]	WES and TS	20 WES, 119 TS	59	4 RNA-seq, 59 CGH,	HiSeq 2000
				125 SNP-array
Gao et al[32]	WES	113 WES	82	-	HiSeq 2000
Zhang et al[35]	WGS and WES	14 WGS, 90 WES	104	-	HiSeq 2000

WGS: Whole-genome sequencing; WES: Whole-exome sequencing; TS: Targeted sequencing; CGH: Comparative genomic hybridization; RNA-seq: RNA sequence; SNP: Single nucleotide polymorphism.