Genotype specific peripheral lipid profile changes with hepatitis C therapy

Table 3 Changes in lipid profile by genotype in patients with cirrhosis and non cirrhosis

	Total population			Non-cirrhotics			Cirrhotics
	Start Tx	End Tx	P value	Start Tx	End Tx	P value	Start Tx	End Tx	P value
Genotype 1
T Chol	156.9 ± 36.4	162.2 ± 41.0	0.005	169.9 ± 33.2	175.7 ± 38.2	0.046	146.4 ± 35.6	151.4 ± 40.0	0.052
HDL	51.6 ± 18.5	63.9 ± 32.8	< 0.001	54.4 ± 19.5	72.7 ± 36.4	< 0.001	49.3 ± 17.2	56.9 ± 27.6	0.002
LDL	80.2 ± 28.8	87.6 ± 62.7	0.058	87.1 ± 28.1	91.8 ± 31.6	0.091	74.6 ± 28.2	84.2 ± 79.1	0.15
TG	114.6 ± 56.0	108.7 ± 56.0	0.044	117.3 ± 55.1	111.6 ± 57.6	0.27	112.5 ± 56.6	106.4 ± 56.5	0.070
Genotype 2
T Chol	162.9 ± 35.8	163.0 ± 32.9	0.99	174.2 ± 29.8	173.7 ± 27.5	0.91	148.2 ± 37.7	148.9 ± 34.1	0.90
HDL	52.8 ± 18.6	54.8 ± 20.0	0.39	54.9 ± 17.4	55.3 ± 17.4	0.88	50.0 ± 19.7	54.0 ± 23.0	0.28
LDL	86.7 ± 34.0	87.4 ± 30.2	0.82	95.3 ± 31.8	96.4 ± 27.0	0.82	75.4 ± 33.4	75.7 ± 30.0	0.93
TG	114.3 ± 64.1	112.4 ± 65.8	0.73	120.6 ± 68.4	124.0 ± 74.2	0.72	106.1 ± 59.7	97.1 ± 48.6	0.078
Genotype 3
T Chol	141.5 ± 38.4	157.6 ± 34.4	< 0.001	161.4 ± 35.5	181.5 ± 23.5	0.001	125.1 ± 32.5	137.9 ± 29.1	0.025
HDL	45.4 ± 15.1	53.3 ± 16.6	0.038	49.3 ± 14.0	53.2 ± 14.3	0.37	42.2 ± 15.3	53.3 ± 18.2	0.065
LDL	81.4 ± 32.1	93.9 ± 34.9	< 0.001	92.5 ± 26.1	110.4 ± 21.4	0.003	72.2 ± 33.6	80.3 ± 37.9	0.045
TG	108.6 ± 47.5	98.8 ± 41.2	0.047	119.0 ± 58.6	112.6 ± 47.1	0.36	100.1 ± 33.4	87.5 ± 31.2	0.12

All values expressed as mean ± SD. All units are in mg/dL. T Chol: Total cholesterol; HDL: High density lipoprotein; LDL: Low density lipoprotein; TG: Triglycerides; Start Tx: Prior to treatment; End Tx: End of treatment.