Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis

doi:10.3748/wjg.v22.i46.10166

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2016; 22(46): 10166-10179
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10166

Table 1 Detailed information on the experimental process

Modeling time	Distribution of operation	Humane	Rabbits	POW 2	POW 4	POW 6	POW 8	POW 10	Humane	Exclusion	Death	Rabbits
Modeling time	Distribution of operation	Termination¹	left²	POW 2	POW 4	POW 6	POW 8	POW 10	Termination³	Exclusion	Death	left⁴
0W	/	0	90	/	/	/	/	/	/	/	/	/
2W	/	0	90	/	/	/	/	/	/		/	/
4W	AAAA	0	82	AAAA	AAAA	AAA⁵	AA	AA	1	1	1	5
4W	BBBB	0	82	BBB	BBB	BBB	BBB	BBB	1	1	1	5
6W	AAAA	0	74	AAA	AAA	AAA	AA	AA	2	0	2	4
6W	BBBB	0	74	BBBB	BBB	BBB	BB	BB	2	0	2	4
8W	AAAA	2	64	AAA	AA	AA	AA	AA	2	0	1	4
8W	BBBB⁵	2	64	BBB	BBB	BB	BB	BB	2	0	1	4
10W	AAAA	3	53	AAA	AAA	AA	AA	AA	2	1	1	4
10W	BBBB	3	53	BBBB	BBB	BBB⁵	BB	BB	2	1	1	4
12W	AAAA	3	42	AAA	AAA	AA	AA	AA	3	0	1	4
12W	BBBB	3	42	BBB	BB	BB	BB	BB	3	0	1	4
14W	AAAA	2	32	AAA	AA	AA	AA	A	5	0	0	2
14W	BBBB⁵	2	32	BBB	BBB	BB	B	B	5	0	0	2
16W	AAAA	4	20	AAAA	AAA	AAA	AA	AA	4	0	1	3
16W	BBBB	4	20	BBB	BB	BB	BB	B	4	0	1	3
18W	AAAA	3	9	AAA	AAA	AAA	AA	AA	4	0	0	3
18W	BBBB⁵	3	9	BBB	BB	BB	B	B	4	0	0	3
20W	AAAA	2	0	AA	AA	AA	AA	A	4	1	0	2
20W	BBB	2	0	BBB	BBB	BB	BB⁵	B	4	1	0	2
Total	68	19	/	/	/	/	/	/	27	3	7	31

¹Number of rabbits with humane termination during Experiment 1;

²Number of rabbits left excluding rabbits with humane termination and failed liver stiffness measurement via ElastPQ during Experiment 1;

³Number of rabbits with humane termination during Experiment 2;

⁴Number of rabbits left excluding rabbits with humane termination, failed liver stiffness measurement via ElastPQ, and death during Experiment 2; A⁵ and B⁵ indicate rabbits with failed LSM via ElastPQ. POW: Postoperative weeks; LSM: Liver stiffness measurement; ElastPQ: Elastography point quantification; A: Rabbits receiving splenectomy and liver biopsy; B: Rabbits receiving only liver biopsy.

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Citation: Wang MJ, Ling WW, Wang H, Meng LW, Cai H, Peng B. Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl₄-induced liver fibrosis. World J Gastroenterol 2016; 22(46): 10166-10179
URL: https://www.wjgnet.com/1007-9327/full/v22/i46/10166.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i46.10166

Wang MJ, Ling WW, Wang H, Meng LW, Cai H, Peng B. Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl₄-induced liver fibrosis. World J Gastroenterol 2016; 22(46): 10166-10179 [PMID: 28028365 DOI: 10.3748/wjg.v22.i46.10166]

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