Elevated fibrinogen plasma level is not an independent predictor of poor prognosis in a large cohort of Western patients undergoing surgery for colorectal cancer

Table 1 Preoperative fibrinogen plasma levels (mg/dL) according to the main demographic and clinical characteristics of the 652 patients under study¹

	No. of patients	Fibrinogen plasma level		P value
		Mean value	± SD
Age (yr)				P = 0.003
≤ 68.8	326	412.1	119.8
> 68.8	326	440.3	125.1
Gender				P = 0.479
Male	373	429.1	128.3
Female	279	422.2	116.2
Tumour location				P = 0.111
Colon	536	429.8	125.0
Rectum	116	409.6	113.7
Type of surgery				P = 0.053
Elective	618	424.0	120.1
Urgent	34	466.0	167.9
Resection				P < 0.001
Yes	640	423.8	121.3
No	12	551.3	162.1
Type of resection (R)				P < 0.001
R0	556	412.4	110.4
R1	7	406.0	113.1
R2	89	513.9	159.6
Depth of invasion (pT)1				P < 0.001
pT1	86	373.7	97.1
pT2	61	373.6	89.8
pT3	259	421.5	111.1
pT4a	141	442.0	143.9
pT4b	93	482.1	118.6
Node involvement (pN)1				P = 0.001
pN0	372	408.2	108.7
pN1	166	445.0	142.6
pN2	102	446.5	119.5
Systemic metastasis (M)				P < 0.001
M0	534	412.1	109.6
M1a	69	466.8	144.1
M1b	49	522.3	170.5
CEA serum level2				P < 0.001
≤ 5 ng/mL	284	393.4	101.0
> 5 ng/mL	130	485.7	129.6

¹Depth of tumour invasion (pT) and nodal involvement (pN) were evaluated in 640 resected patients;

²CEA serum level was available for 414 patients.