Carbon monoxide contributes to the constipating effects of granisetron in rat colon

Figure 1 Effect of in vivo administration of granisetron on the time to first defecation. In vivo treatment with granisetron (G) significantly increased the time to first defecation at doses of 50 and 75 μg/kg. Friedman’s test = 13 P = 0.005, post hoc: G 25 μg/kg vs vehicle, P = 0.132; G 50 μg/kg vs vehicle, ^aP = 0.045; G 75 μg/kg vs vehicle, ^bP = 0.045. Each point represents an individual observation.