Neuroendocrine neoplasms of liver - A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification

Figure 4 Signet ring cell neuroendocrine neoplasm, G2. A: Tumor cells arranged in sheets and composed of polygonal cells with abundant clear to vacuolated cytoplasm and eccentrically placed uniform nuclei (H&E × 200); B: Occasional tumor cells containing pale staining cytoplasmic mucin (arrows) (PAS-D × 200); C: Tumor cells displaying diffuse cytoplasmic positivity for synaptophysin (immunohistochemistry × 200); D: Tumor cells displaying diffuse cytoplasmic positivity for chromogranin (immunohistochemistry × 200).