Meta-Analysis
Copyright ©The Author(s) 2016.
World J Gastroenterol. Oct 21, 2016; 22(39): 8831-8843
Published online Oct 21, 2016. doi: 10.3748/wjg.v22.i39.8831
Table 2 Key characteristics of individual studies
StudyPatient registryDiagnosis method of LGDBiopsy details
Picardo et al[27] 2015Specialist center based registryExpert pathologist panel: 2 pathologists required to make diagnosisFour-quadrant biopsies every 1 cm of Barrett's esophagus
Duits et al[28] 2014Specialist center based registryExpert pathologists panel: At-least 2 pathologists required to make diagnosisH&E stained slides of paraffin embedded biopsy specimens
von Rahden et al[29] 2008Specialist center and Community population based registryExpert pathologists panel: 3 pathologists required to make diagnosisMultiple biopsies at different levels of Barrett’s esophagus
Lim et al[30] 2007Specialist center based registryExpert pathologists panel: 5 pathologists required to make diagnosisFour to ten (sometimes more) biopsies taken from Barrett's area. Hematoxylin and eosin staining
Vieth et al[31] 2006Specialist center based registryBiopsies assessed twice by two pathologists in a blinded fashionFour biopsies every 2 cm in relation to the Barrett’s esophagus length
Basu et al[32] 2004Community based cohortExperienced gastrointestinal pathologist assessed histological sections, with confirmation by a colleague if high-grade dysplasia or worse was suspected. All cases of low-grade dysplasia were reviewed at a regular gastrointestinal histopathology meeting2-cm interval quadrantic biopsies in the entire length of Barrett’s esophagus
Montgomery et al[33] 2001Specialist center based registryExpert pathologists panel: 12 pathologists required to make diagnosis - reviewed blindly twice by each pathologistMultiple biopsies at different levels of Barrett’s esophagus. Submitted biopsy specimen had to show the worst lesion that the patient was known to have at the time of the initial known endoscopy
Skacel et al[34] 2000Specialist center based registryExpert pathologists panel: LGD cases were randomized and blindly reviewed by three gastrointestinal pathologistsFour-quadrant biopsies taken using jumbo forceps at intervals of < 2 cm throughout the length of the Barrett’s segment, with additional biopsies of any endoscopic lesions. All biopsy specimens had been fixed in formalin or Hollande’s solution
Younes et al[45] 2011Specialist center based registryExpert pathologist panel: 2 pathologists required to make diagnosisBiopsies from two or more levels in barrett's esophagus. Hematoxylin-eosin–stained sections of formalin-fixed and paraffin-embedded tissue
Wani et al[10] 2011Specialist center based registryConsensus diagnosis among two or more pathologists: defined as agreement between the local GI pathologist and expert central pathologistsAt least 4 quadrant biopsies every 2 cm with either a standard or jumbo biopsy forceps. Hematoxylin Eosin stained slides of paraffin-embedded biopsy specimens
Curvers et al[36] 2010Community based cohortExpert pathologist panel: 2 pathologists required to make diagnosisAll visible abnormalities were sampled, followed by random sampling of the Barrett segment in four quadrants every 2 cm. Hematoxylin and eosin stained slides of paraffin-embedded biopsy specimens
Srivastava et al[37] 2007Specialist center based registryExpert pathologists panel: 3 pathologists required to make diagnosisFour-quadrant endoscopic esophageal mucosal biopsies were obtained at every 1–2 cm. All four-quadrant Hollande’s or formalin fixed biopsies were embedded into one paraffin block and serial 4 µm thick tissue sections were cut and stained with hematoxylin and eosin