Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis

Figure 6 Combination of villus height and crypt depth as a representation of overall mucosal thickness in female Dark Agouti rats. Effects of RE and 5-FU on villus height and crypt depth in female Dark Agouti rats. Rats received a daily water, HDR or LDR gavage for an 8-d trial period and an intraperitoneal injection of 5-FU or saline on Day 5. Mean values were significantly different vs water + 5-FU (^cP < 0.05, ^fP < 0.001). ^aP < 0.05, ^eP < 0.001 vs water + saline. JI: Jejuno-ileum; LDR: Low-dose RE; HDR: High-dose RE; RE: Rhubarb extract.