Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum

Table 3 Overview matrix metalloproteinases[124]

MMP	Name	Producing Cells	Substrates
MMP-1	Collagenase	Fibroblasts, synovial cells, chondrocyte	Collagen I, II, III, X
MMP-2	Gelatinase	Fibroblasts, chrondrocyte, mesangium	Gelatin, collagen IV, V, VII, XI
		endothelial cells, cancer cells	Laminin, fibronectin, elastin
MMP-3	Stromelysin-1	Synovial cells, chondrocyte, fibroblasts	Proteoglycan, collagen III, IV, VII, IX, elastin
MMP-7	Matrilysin	Cancer cells, macrophage	Proteoglycan, gelatin, fibronectin
			elastin, collagen IV, laminin
MMP-8	Neutrophil, Collagenase	Neutrophil	Collagen I, II, III
MMP-9	Gelatinase B	Neutrophil, macrophage, thromboblast	Gelatin, collagen III, IV, V
		osteoclast, cancer cells, T-lymphocyte	α2 chain, Elastin
MMP-10	Stromelysin-2	Cancer cells, T-lymphocyte	Collagen III, IV, V, fibronectin, gelatin
MMP-11	Stromelysin-3	Cancer cells, macrophage, mesangium	Fibronectin, laminin, proteoglycan, gelatin
MMP-12	Metalloestelase	Macrophage	Elastin
MMP-13	Collagenase-3	Chondrocyte, cancer cells	Collagen I, II, III
MMP-14	MT1-MMP	Cancer cells, fibroblasts	Collagen I, II, III, gelatin, Laminin
			Fibronectin, vitronectin, proteoglycan
MMP-15	MT2-MMP	Cancer cells, fibroblasts	Fibronectin, aggrecan, tenascin
MMP-16	MT3-MMP	Neuronal cell	Collagen III, gelatin, fibronectin
MMP-17	MT4-MMP	Unknown	Unknown
MMP-20	Enamelysin	Odontoblast	Amelogenin, gelatin
MMP-24	MT5-MMP	Unknown	Unknown
MMP-25	MT6-MMP	Unknown	Unknown
TIMP-1		Tissue, extracellular fluid	Complex formation with pro-MMP-9 and MMPs
TIMP-2		Tissue, extracellular fluid	Complex formation with pro-MMP-9, inhibition of MMP-2 degradation

MMP: Matrix metalloproteinases; TIMP: Tissue inhibitor metalloproteinases.