Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury

Figure 10 Hepatocellular cell death is significantly less on Haemoxygenase induction (PDTC + ischemia reperfusion) in hepatic ischemia reperfusion. A: Hepatocellular death early phase; B: Hepatocellular death late phase. Preconditioning (RIPC + IRI) reproduces effects of HO induction as Hepatocellular cell death in RIPC + IR is significantly less compared to IRI group. HO inhibition prior to preconditioning (ZnPP + RIPC + IR) significantly enhances hepatocellular death in preconditioned animals. Values expressed as mean ± SE. RIPC: Remote ischemic preconditioning; IRI: Ischemia reperfusion injury.