Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma

Figure 2 Expression and clinicopathological characteristics of heterogeneous nuclear ribonucleoprotein H1 mRNA presented in the cancer genome atlas RNA sequencing dataset. A: Transcript models for HNRNPH1 in hg19 visualized in the NCBI RefSeq. Human HNRNPH1 was encoded on the reverse strand. Two transcript variants were transcribed with different 5’UTR region. The light grey represents the untranslated region, while dark grey represents the coding region; B: These two transcripts had different expression patterns in ESCC. NT, non-tumor tissues (n = 11); T, tumor tissues (n = 87); C: The correlation analysis between variant 1 and 2 in the tumor tissues of ESCC (n = 87). Pearson correlation coefficients were calculated between their mRNA levels; D and E: The clinicopathological characteristics analysis of variant 1 (D) and variant 2 (E) expression in the Asian ESCC cases (n = 40). T staging, tumor invasive depth; N staging, lymph node metastasis; AJCC staging, the 7^th edition cancer staging of American Joint Committee on Cancer. HNRNPH1: Heterogeneous nuclear ribonucleoprotein H1; ESCC:Esophageal squamous cell carcinoma; UTR: Untranslated region.