Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo

Table 5 Relative IOD of MRP1 expression in experimental groups and control group (mean ± SD)

Group	24 h	48 h	72 h	120 h	168 h
Control	1.31 ± 0.36	1.33 ± 0.08	1.09 ± 0.24	1.22 ± 0.35	1.07 ± 0.22
5-FU	1.27 ± 0.10	1.31 ± 0.11	1.14 ± 0.16	1.20 ± 0.31	1.13 ± 0.14
rAd-p53	0.98 ± 0.09	0.74 ± 0.11	0.58 ± 0.18	0.87 ± 0.31	0.31 ± 0.08
5-FU + rAd-p53	0.71 ± 0.17	0.62 ± 0.02	0.51 ± 0.10	0.42 ± 0.08	0.13 ± 0.10
F	6.438	123.754	20.567	15.512	36.073
P value	0.016	0	0	0.001	0
P value	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05
5-FU vs Control
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs Control
P value	> 0.05	< 0.05	> 0.05	< 0.05	> 0.05
rAd-p53 + 5-FU vs rAd-p53
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs 5-FU
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs 5-FU