Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo

Table 4 Relative IOD of P-gp expression in experimental groups and control group (mean ± SD)

Group	24 h	48 h	72 h	120 h	168 h
Control	1.28 ± 0.20	1.32 ± 0.31	1.36 ± 0.40	1.29 ± 0.43	1.30 ± 0.56
5-FU	1.17 ± 0.37	1.13 ± 0.41	1.17 ± 0.39	1.27 ± 0.47	1.29 ± 0.56
rAd-p53	1.12 ± 0.31	0.69 ± 0.11	0.62 ± 0.02	0.36 ± 0.15	0.26 ± 0.06
5-FU + rAd-p53	0.86 ± 0.17	0.65 ± 0.21	0.59 ± 0.25	0.31 ± 0.01	0.10 ± 0.03
F	5.670	7.301	14.645	9.844	7.971
P value	0.022	0.011	0.001	0.005	0.009
P value	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05
5-FU vs Control
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs Control
P value	< 0.05	> 0.05	> 0.05	> 0.05	> 0.05
rAd-p53 + 5-FU vs rAd-p53
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs 5-FU
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs 5-FU