Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo

Table 3 Relative IOD of protein kinase C expression in experimental groups and control group (mean ± SD)

Group	24 h	48 h	72 h	120 h	168 h
Control	1.13 ± 0.08	1.21 ± 0.06	0.99 ± 0.13	1.26 ± 0.42	1.08 ± 0.20
5-FU	0.94 ± 0.21	1.12 ± 0.14	0.93 ± 0.14	1.08 ± 0.52	1.04 ± 0.26
rAd-p53	0.93 ± 0.42	0.91 ± 0.23	1.07 ± 0.13	0.57 ± 0.18	0.36 ± 0.09
5-FU + rAd-p53	1.23 ± 0.24	0.53 ± 0.09	0.45 ± 0.10	0.26 ± 0.06	0.08 ± 0.01
F	1.036	33.972	14.348	24.072	71.559
P value	0.427	0	0.01	0	0
P value	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05
5-FU vs Control
P value	> 0.05	< 0.05	> 0.05	< 0.05	< 0.05
rAd-p53 vs Control
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd/p53 + 5- FU vs Control
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs rAd-p53
P value	> 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs 5-FU
P value	> 0.05	< 0.05	> 0.05	< 0.05	< 0.05
rAd-p53 vs 5-FU