Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo

Table 2 Relative IOD of p53 expression in experimental groups and control group (mean ± SD)

Group	24 h	48 h	72 h	120 h	168 h
Control	0.099 ± 0.001	0.105 ± 0.003	0.101 ± 0.007	0.105 ± 0.015	0.103 ± 0.001
5-FU	0.108 ± 0.002	0.098 ± 0.028	0.096 ± 0.004	0.097 ± 0.047	0.096 ± 0.033
rAd-p53	0.187 ± 0.003	0.209 ± 0.014	0.627 ± 0.005	0.743 ± 0.012	0.713 ± 0.005
5-FU + rAd-p53	0.393 ± 0.004	0.461 ± 0.002	0.691 ± 0.018	0.822 ± 0.009	0.808 ± 0.027
F	221.565	270.392	3983.173	9639.595	3867.703
P value	0	0	0	0	0
P value	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05
5-FU vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs rAd-p53
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs 5-FU
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs 5-FU