Synergistic anticancer effect of exogenous wild-type p53 gene combined with 5-FU in human colon cancer resistant to 5-FU in vivo

Table 1 Tumor apoptosis ratios in experimental groups and control group (mean ± SD)

Group	24 h	48 h	72 h	120 h	168 h
Control	0.25 ± 0.02	0.28 ± 0.01	0.27 ± 0.02	0.29 ± 0.02	0.24 ± 0.04
5-FU	0.27 ± 0.03	0.31 ± 0.03	0.31 ± 0.05	0.30 ± 0.04	0.31 ± 0.02
rAd-p53	0.29 ± 0.02	0.35 ± 0.03	0.43 ± 0.08	0.42 ± 0.06	0.46 ± 0.06
5-FU + rAd-p53	0.33 ± 0.03	0.44 ± 0.08	0.58 ± 0.07	0.59 ± 0.05	0.62 ± 0.07
F	13.235	41.487	53.812	61.676	80.755
P value	0	0	0	0	0
P value	> 0.05	> 0.05	> 0.05	> 0.05	> 0.05
5-FU vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs Control
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs rAd-p53
P value	< 0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 + 5-FU vs 5-FU
P value	>0.05	< 0.05	< 0.05	< 0.05	< 0.05
rAd-p53 vs 5-FU