Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate

Table 3 Role of probiotics in irritable bowel syndrome

Ref.	Diagnostic criteria	No. participant	Probiotic	Time (wk)	Results (vs placebo)
O’Sullivan et al[147]	Rome	25	Lactobacillus GG	20	No difference
Nobaek et al[148]	Rome	60	L. plantarum	4	↓ pain and flatulence
Kim et al[149]	Rome II	25	VSL#3	8	↓ bloating
O’Mahony et al[150]	Rome II	80	L. salivarius UCC4331, B. infantis 35624	8	↓ symptoms and pro-inflammatory cytokines (only for B. infantis)
Kajarder et al[151]	Rome/Rome II	103	Mixture of L. rhamnosus GG, L. rhamnosus LC705, B. breve Bb99, P. freudenreichii	24	↓ symptoms
Kim et al[152]	Rome II	48	VSL#3	8	↓ flatulence
Niv et al[153]	Rome II	54	L. reuteri ATCC55730	24	No difference
Whorwell et al[154]	Rome II	362	B. infantis 35624	4	↓ symptoms (only at dose of 1 × 108 CFU)
Guyonnet et al[155]	Rome II (C-IBS)	274	B. animalis DN173010	4	↑ QoL and bloating score
Kajander et al[156]	Rome II	86	L. rhamnosus GG, L. rhamnosus Lc705, P. freudenreichii sp P. Shermanii JS, B. animalis sp P. lactis Bb-12	20	↓ bloating and abdominal pain
Zeng et al[157]	Rome II (D-IBS)	29	S. thermophilus, L. bulgaricus, B. longum	4	↓intestinal permeability and symptoms
Drouault-Holowazcz et al[158]	Rome II	100	B. longum LA101, L. acidophilus LA102, Lactocuccus lactis LA103, S. thermophilus LA104	4	↑ QoL
					↓ flatulence, pain and bloating
Sinn et al[159]	Roma III	40	L. acidophilus SDC 2012, 2013	4	↓ symptoms
Simrén et al[160]	Rome II	74	L. paracasei F19, L. acidophilus La5, B. lactis Bb-12	8	No difference
Søndergaard et al[161]	Rome II	52	L. paracasei F19, L. acidophilus La5, B. lactis Bb-12	8	No difference
Guglielmetti et al[162]	Rome III	122	B. bifidum MIMBb75	4	↓ symptoms ↑ QoL
Ducrotté et al[163]	Rome III (D-IBS)	214	L. plantarum 299v	4	↓ pain and bloating
Kruis et al[164]	Rome II (D-IBS)	120	E. coli Nissle 1917	12	No difference
Ki Cha et al[165]	Roma III (D-IBS)	50	L. acidophilus, L. plantarum, L. rhamnosus, B. breve, B. lactis, B. longum, S.thermophilus	8	↑ QoL
Dapoigny et al[166]	Rome III	50	L. caseirhamnosus	4	↓ symptoms
Roberts et al[167]	Rome III	179	B. lactis CNCMI-2494	12	No difference
Shavatehi et al[168]	Rome II	160	Lactobacillus, Bifidobacterium strains and Streptococcus thermophiles	2	No difference
Yoon et al[169]	Rome III	80	L. acidophilus, L. rhamnosus, B. breve, B. actis, B. longum, S.thermophilus	4	↓ symptoms
Pineton de Chambrun et al[170]	Rome III	179	S. cerevisiae	8	↓ pain and discomfort

All the studies are randomized controlled trials vs placebo. QoL: Quality of life.