Risk factor for ischemic-type biliary lesion after ABO-incompatible living donor liver transplantation

Table 3 Comparison of ABO-incompatible adult living donor liver transplantation recipients between ischemic-type biliary lesion group and non-ischemic-type biliary lesion group

	ITBL group (n = 4)	non-ITBL group (n = 23)	P value
Preoperative characteristics
Recipient age (yr)	51 (47-53)	49 (31- 65)	0.721
Recipient sex (M/F)	3/1	18/5	1.000
Donor age (yr)	22 (21-37)	24 (18-53)	0.545
Donor BMI	21.6 ± 2.5	22.8 ± 3.2	0.495
Blood type-A barrier	3 (75%)	17 (73.9%)	1.000
MELD	13 (9-25)	10 (6-34)	0.567
CTP score	7 (5-11)	5 (5-12)	0.322
Initial isoagglutinin titer
IgG (≥ 1:64)	2 (50%)	10 (43.5%)	1.000
IgM (≥ 1:64)	2 (50%)	9 (39.1%)	1.000
No. of PE (preoperative)	2.5 (0-5)	2 (0-15)	0.802
Initial B-cell (%)	17.7 ± 3.7	16.2 ± 1.5	0.945
Operative outcomes
Operation time (min)	678.3 ± 28.8	645.6 ± 90.8	0.336
Actual graft weight (g)	585.5 ± 135.6	682.3 ± 105.9	0.117
Actual GRWR (%)	0.87 ± 0.29	0.99 ± 0.24	0.373
Cold ischemic time (min)	149.3 ± 28.7	114.4 ± 53.3	0.219
Warm ischemic time (min)	48.7 ± 11.8	45.8 ± 12.3	0.659
Intra-operative transfusion (unit)
RBC	1.7 ± 1.5	2.9 ± 3.9	0.572
FFP	1.7 ± 2.1	2.3 ± 2.7	0.678
P-conc.	2.0 ± 4.0	7.1 ± 6.7	0.159
HAIT	1 (25%)	5 (21.7%)	1.000
Postoperative outcomes
Peak level of AST (IU/L)	330.2 ± 240.7	223.5 ± 151.3	0.258
Peak level of ALT (IU/L)	435.0 ± 444.5	323.0 ± 230.5	0.462
Peak level of total bilirubin (mg/dL)	5.5 ± 2.2	3.9 ± 1.4	0.071
Peak isoagglutinin titer
IgG (≥ 1:64)	2 (50%)	4 (17.4%)	0.204
IgM (≥ 1:64)	1 (25%)	3 (13.1%)	0.279
No. of PE (postoperative)	2 (0-4)	0 (0-6)	0.090
Post-operative transfusion (unit)
RBC	2.3 ± 2.6	2.8 ± 4.2	0.811
FFP	0.5 ± 1.0	4.8 ± 7.5	0.264
P-conc.	9.0 ± 2.0	11.5 ± 13.7	0.721
Post-LT ICU stay (d)	4 (1-5)	4 (3-6)	0.900
Post-LT hospital stay (d)	39 (28-51)	28 (20-75)	0.277
BPACR	1 (25%)	5 (21.7%)	1.000
BPAMR	1 (25%)	0	0.148
Complications
Post-LT hemorrhage	0	4 (17.4%)	1.000
CMV infection	0	7 (30.4%)	0.545
Bacterial infection	0	1 (4.3%)	1.000
B-cell follicle score in spleen	3.7 ± 0.5	2.6 ± 1.1	0.067
Plasma cell count in spleen	73.0 ± 19.0	76.8 ± 47.9	0.878

ABO-I ALDLT: ABO-incompatible adult living donor liver transplantation; ITBL: Ischemic-type biliary lesion; BMI: Body mass index; MELD: Model for end-stage liver disease; CTP: Child-Turcotte-Pugh; PE: Plasma exchange; GRWR: Graft-to-recipient weight ratio; RBC: Red blood cell; FFP: Fresh frozen plasma; P-conc.: Platelet concentrate; HAIT: Hepatic artery infusion therapy; AST: Aspartate transaminase; ALT: Alanine transaminase; LT: Liver transplantation; ICU: Intensive care unit; BPACR: Biopsy-proven acute cellular rejection; BPAMR: Biopsy-proven antibody-mediated rejection; CMV: Cytomegalovirus.