Noninvasive models for assessment of liver fibrosis in patients with chronic hepatitis B virus infection

Table 3 Performance of noninvasive tests for identification of fibrosis in hepatitis B virus-infected patients with normal or minimally elevated serum alanine transaminase

Ref.	Year	n	Fibrosis	Cutoff	AUC	Se/Sp, %	PPV/NPV, %
Zeng et al[30]	2014	278	F4	0.62	0.830	86.7/75.0	49.6/95.2
FIB-4
Seto et al[59]	2011	237	F2		0.726	NA	NA
Wang et al[35]	2013	239	F2		0.770	54/85	86/78
			F3		0.810	67/80	37/97
APRI
Seto et al[59]	2011	237	F2		0.727	NA	NA
Wang et al[35]	2013	239	F2		0.770	59/79	59/70
			F3		0.770	63/72	28/94
Park et al[69]	2011	124	F3	16.5	0.800	90.6/50.0	NA
				18.5	0.800	31.3/89.5	NA
Seto et al[59]	2011	237	F2		0.797	NA	NA
Wang et al[70]	2015	283	F2		0.820	NA	NA

AUC: Area under receiver operating curve; NA: Not available; NPV: Negative predictive value; PPV: Positive predictive value.