Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

Table 1 Clinical characteristics of the study subjects

	Hepatitis B-associated HCC(n = 30)	Hepatitis C-associated HCC(n = 38)	P value
Sex (M/F)	28/2	22/16	< 0.011
Age (yr)	62.6 ± 10.9	73.4 ± 9.7	< 0.012
Albumin (g/dL)	3.4 ± 0.6	3.4 ± 0.5	NS2
Total bilirubin (mg/dL)	1.2 ± 0.6	1.4 ± 1.3	NS2
AST (U/L)	75.6 ± 76.2	57.8 ± 31.6	NS2
ALT (U/L)	54.3 ± 38.4	49.8 ± 38.3	NS2
Fasting blood glucose (mg/dL)	104.5 ± 22.2	113.1 ± 36.0	NS2
γ-glutamyl transferase (U/L)	77.0 ± 64.8	60.4 ± 58.1	NS2
Creatinine (mg/dL)	0.73 ± 0.19	1.01 ± 1.53	NS2
Platelet count (× 103/μL)	13.5 ± 8.4	11.7 ± 4.7	NS2
Fib-4 index	5.7 ± 4.4	6.4 ± 3.9	NS2
AFP (ng/mL) ≤ 6.2 /> 6.2	10/20	8/30	NS1
DCP (mAU/mL) ≤ 40 /> 40	17/13	24/14	NS1
HBs antigen, positive	30	0
HCV-antibody, positive	0	38
HBV genotype (A/B/C/D)	0/14/15/1	NA
HCV genotype (1b/2a/2b)	NA	34/4/0

¹Fisher exact test;

²Mann-Whitney U-test. Data were expressed as mean ± SD. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; NS: Not significant; NA: Not applicable; DCP: Des-γ-carboxy prothrombin; HCC: Hepatocellular carcinoma.