Selective intestinal decontamination for the prevention of early bacterial infections after liver transplantation

Table 1 Characteristics of randomized trials evaluating selective intestinal decontamination in liver transplant

Ref.	Type of study	SID regimen	Treatment perioperative (48 h)	Patients (n)		Patients with infection, n (%)		Period of observation posttransplantation (d)
				SID	Control	SID	Control
Bion et al[50], 1994	Randomized trial not placebo controlled	Tobramycin, amphotericin and polymyxin B for 5-15 d posttransplantation	Cefotaxime and ampicillin	21	31	3 (14.3)	12 (38.7)	15 d or until hospital discharge
Arnow et al[51], 1996	Randomized trial not placebo controlled	Gentamicin, polymyxin and nystatin orally for 21 d posttransplantation	Cefotaxime and ampicillin	36	33	14 (38.9)	14 (42.4)	28
Hellinger et al[53], 2002	Randomized placebo-controlled trial	Gentamicin, polymyxin E and nystatin 4 x/d for 21 d posttransplantation	Ceftizoxime	37	43	12 (32.4)	12 (28.9)	60
Zwaveling et al[28], 2002	Randomized placebo-controlled trial	Norfloxacin, colitin,tobramycin and amphotericin B	Cefotaxime and tobramycin	29	29	22 (75.9)	25 (86.2)	30

SID: Selective intestinal decontamination.