Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

Table 1 Baseline characteristics of patients with chronic hepatitis B

Variables	n = 240
Age, yr1	48 (27-86)
Gender, M/F	201/39 (84/16)
1Platelet, × 103/mm3	176 (62-556)
Prothrombin time, %1	87 (30-147)
ALT, IU/L1	149 (10-2170)
Total bilirubin, mg/dL1	0.8 (0.3-15.4)
Albumin, g/dL1	4.1 (2.2-5.2)
Serum AFP, ng/mL1	5.9 (1-2150)
Child-Pugh class, A/B/C	216/15/0 (94/6/0)
HBeAg positivity	195 (81)
Serum HBV DNA, copies/mL1	4.2 × 106 (ND-1.1 × 109)
Presence of HBV genotype C	240 (100)
Follow-up periods, mo1	105 (1-237)

¹Median (range). ALT: Alanine aminotransferase; AFP: α-fetoprotein; HBeAg: Hepatitis B e antigen; ND: Not-detected.