Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-II expression on dendritic cells in chronic hepatitis C infection

Figure 4 Multigroup plot showing A: up-regulation of down modulatory genes (negative regulators) in MDC-NR (non-responders) as compared to MDC-R (responders); B: Down-regulated genes in MDC-NR (Non-responders) as compared to the MDC-R (Responders); C: Down-regulation of genes involved with DC maturation and co-stimulatory molecules in the cells differentiated in the presence of viral antigens (moDC-Ag) as compared to cells without antigens (moDC-N). The genes which are negative regulators of JAK-STAT such as suppressors of cytokine signaling (SOCS), protein inhibitors of activated STATs are up-regulated in non-responders as compared to responders whereas the genes which belong to MHC class II family such as HLA-DPB1, HLA-DQA1 and HLA-DQB1 and dendritic cell maturation marker such as CD83 is down-regulated in non-responders as compared to responders.