Endoscopy-based management decreases the risk of postoperative recurrences in Crohn’s disease

Table 4 Univariate analysis of risk factors for surgical postoperative recurrence in Crohn’s disease

	Median time to surgical POR (mo)	HR [95%CI]	P value
Age		1.00 [0.99-1.01]	0.29
Age
< 35 yr	218.3	Reference
≥ 35 yr	131.6	1.32 [0.77-2.26]	0.30
Age at diagnosis
≤ 16 yr		Reference
16-40 yr	144.0	1.37 [0.42-4.42]	0.60
≥ 40 yr	108.6	1.73 [0.45-6.54]	0.42
Tobacco use
Non-smoker	136.2	Reference
Active smoker	173.4	0.84 [0.46-1.52]	0.56
Previous intestinal resection
No	173.4	Reference
Yes	108.6	1.74 [1.01-3.00]	0.04
Total resection length > 50 cm
No	136.2	Reference
Yes	120.0	1.50 [0.67-3.34]	0.32
Disease behavior (Montreal classification)
B1		Reference
B2	162.1	3.93 [0.52-29.33]	0.18
B3	128.8	5.71 [0.77-42.23]	0.09
Fistulizing Crohn’s disease (B3)
No	165.4	Reference
Yes	128.8	1.78 [1.04-3.05]	0.03
Perianal lesions
No	136.2	Reference
Yes	151.1	0.99 [0.58-1.69]	0.97
Type of perianal lesions
Non-fistulizing lesions	156.9	Reference
Fistula, abscess	144.0	1.14 [0.66-1.97]	0.63
Disease duration		1.00 [0.99-1.01]	0.67
Ileal resection > 50 cm
No	136.2	Reference
Yes	120.0	1.23 [0.29-5.16]	0.78
Prior exposure to anti-TNF therapy before surgery
No	151.1	Reference
Yes	.	1.62 [0.92-7.08]	0.07
Thiopurines therapy in prevention of surgical postoperative recurrence
No	144.0	Reference
Yes	151.1	0.91 [0.50-1.65]	0.75
Anti-TNF therapy in prevention of surgical postoperative recurrence
No	156.9	Reference
Yes	136.2	2.09 [1.14-3.81]	0.02
Period of surgery
1986-1999		Reference
2000-2015		1.85 [1.22-2.80]	0.004

CRP: C-reactive protein; TNF: Tumor necrosis factor.