How important is donor age in liver transplantation?

Table 1 Studies that analyze impact of donor age on liver transplant outcomes

Ref.	Type of donor	Cut-off age	No. of patients	Outcomes
Adam et al[1]	Deceased donor	< 55 yr vs > 65 yr	80347	Higher graft survival with donors younger than 55 yr
Adam et al[2]	Deceased donor	Multiple age groups	41522	No differences in one-year survival
Cuervas-Mons et al[3]	Deceased donor	55 yr	18568	Lower graft 5-yr survival rate with older donors
Feng et al[10]	Deceased donor	60 yr	20023	Higher rate of graft failure with older donors
Reese et al[11]	Deceased donor	45 yr	14756	Higher rate of graft failure at 90 d after LT with older donors
Serrano et al[12]	Deceased donor	60 yr	149	Lower graft survival rate with older donors
Anderson et al[13]	Deceased donor	60 yr	741	No differences were observed
Alamo et al[14]	Deceased donor	70 yr	129	No differences were observed in selected recipients (non HCV, low MELD, younger than 60 yr)
Kim et al[15]	Deceased donor	65 yr	100	Donor age should not be an absolute contraindication
Han et al[16]	Living donor	55 yr	604	Higher mortality rate with older donors
Dayangac et al[17]	Living donor	50 yr	150	Higher rate of major complication with older donors
Ikegami et al[18]	Living donor	< 30 yr vs > 50 yr	34	Better graft function and regeneration rates with donors < 30 yr
Ikegami et al[19]	Living donor	50 yr	232	Higher rate of small for size syndrome with older donors
Iwamoto et al[20]	Living donor	50 yr	232	Worse survival and high bilirubin levels with older donors
Ono et al[21]	Living donor	< 30 yr vs > 50 yr	15	Lower regeneration rate a week after LT with older donors
Uchiyama et al[22]	Living donor	48 yr	321	Higher rate of small for size syndrome with older donors
Li et al[23]	Living donor	70 yr	129	No differences in recipient survival rate at 1, 3 and 5 yr
Wang et al[24]	Living donor	50 yr	159	No differences in recipient survival rate at 1, 3 and 5 yr

LT: Liver transplantations; HCV: Hepatitis C virus; MELD: Model for End-stage Liver Disease.