Clinical and ABCB11 profiles in Korean infants with progressive familial intrahepatic cholestasis

Figure 2 Liver histologic features from infants with chronic intrahepatic cholestasis with normal ranges of γ-glutamyl transpeptidase. A: Hepatocellular carcinoma was confirmed by liver specimen at hepatectomy taken from patient 1 at 24 mo of age. Cellular atypia with trabecular and acinar type was shown. Microvascular invasion was not identified; hematoxylin-eosin stain, original magnification × 400; B: Electron microscopic examination of liver specimen from patient 2 shows many globular or curly appearance electron dense materials in the cytoplasm with original magnification of × 3.5k; C: Liver biopsy at hepatectomy taken at 6 months of age from patient 3 shows periportal fibrosis, inflammatory cell infiltration, intracanalicular bile plugs, giant cell formation, and bile ductular proliferation; hematoxylin-eosin stain, original magnification × 200; D: Electron microscopic examination of liver specimen from patient 4 at 3.5 mo of age reveals amorphous and coarse granular bile pigments in the dilated bile canaliculi. Original magnification × 5.0k; E: Electron microscopic examination of liver specimen from patient 5 shows aggregated bile pigments in the cytoplasm. Original magnification × 2.5k.