Precore/core region mutations of hepatitis B virus related to clinical severity

Table 2 Mutations in the hepatitis B virus preC/C region leading to change of HBeAg serostatus in chronic patients

Regions	Mutations				HBV genotype	MHC class	HBeAg serostatus (P value)	Ref.
	Amino acid	Changes	Nucleotide	Changes
preCore	28	W28Stop	1896	G1896A	A/B/C/C2/D		N (n = 14) vs P (n = 3) (P = 0.004)	[27]
							eAg Seroconverters (n = 14 of 29, 48.3%)	[73]
							N (43.4%) vs P (11.9%) (P = 0.001)	[72]
							N (61.5%) vs P (10.9%) with HIV/HBV (P ≤ 0.0001)	[77]
Core	5	P5R	1914	C1914G	A/D	II	N (23.4%) vs P (4.7%) (P = 0.001)	[72]
	32	D32N/H	1994	G1994A/C	C2	Immuno-inactive	N (n = 2) vs P (n = 7) (P = 0.074)	[27]
	43	E43K	2027	G2027A	C2	Immuno-inactive	N (n = 1) vs P (n = 7) (P = 0.024)	[27]
	50	P50Y/H/A	2048-2049	C2048T/G, C2049A	C2	II	N (n = 5) vs P (n = 0) (P = 0.020)	[27]
	131	A131P/N/G	2291-2293	G2291C/A, C2292A/G, T2293C	C2	II	N (n = 4) vs P (n = 0) (P = 0.039)	[27]
	135	P135Q	2304	C2304A	B	I	eAg Seroconverters (n = 18 of 29, 62.1%)	[73]
	181	S181P/H	2441-2442	T2441C, C2442A	C2	Immuno-inactive	N (n = 4) vs P (n = 0) (P = 0.039)	[27]

MHC: Major histocompatibility complex; N: Negative; P: Positive.