Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease

Figure 1 General histology and immunohistochemical detection of phosphatase and tensin homolog protein expression in the liver of healthy donor (hepatic resections) or patients with different stages of non-alcoholic fatty liver disease (liver biopsies). Liver sections of healthy donors (A and B) or of obese patients with steatosis (n = 10, C and D), nonalcoholic steatohepatitis (n = 14, E and F), fibrosis (n = 12, G and H) and cirrhosis (n = 8, I and J) were either stained with hematoxylin eosin (A, C, E), Masson’s trichrome (G and I) or immunostained with anti-PTEN antibody (B, D, F, H and J). The inset in image (E) shows hepatic intralobular inflammation characterized by neutrophils (arrow) and ballooning hepatocyte (star). Scale bar = 100 μm. PTEN: Phosphatase and tensin homolog.