Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2016; 22(13): 3632-3643
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3632

Table 4 Adverse events related to sorafenib administration n (%)

Adverse event	Mono-therapy of sorafenib			TACE combined with sorafenib
Adverse event	All events	Grade 1-2 events	Grade 3-4 events	All events	Grade 1-2 events	Grade 3-4 events
Overall incidence	14 (93.3)	12 (80.0)	2 (13.3)	30 (90.9)	26 (78.8)	4 (12.1)
Alopecia	6 (40.0)	6 (40.0)	0 (0.0)	11 (33.3)	11 (33.3)	0 (0.0)
Anorexia	4 (26.7)	4 (26.7)	0 (0.0)	18 (54.5)	18 (54.5)	0 (0.0)
Diarrhea	13 (86.7)	12 (80.0)	1 (6.7)	27 (81.8)	26 (78.8)	1 (3.0)
Epistaxis	1 (6.7)	1 (6.7)	0 (0.0)	2 (6.0)	2 (6.0)	0 (0.0)
Fatigue	12 (80.0)	12 (80.0)	0 (0.0)	22 (66.7)	21 (63.6)	1 (3.0)
Gastrointestinal hemorrhage	1 (6.7)	1 (6.7)	0 (0.0)	1 (3.0)	1 (3.0)	0 (0.0)
Hand-foot skin reactions	11 (73.3)	10 (66.7)	0 (0.0)	12 (36.3)	11 (33.3)	1 (3.0)
Liver dysfunction	4 (26.7)	4 (26.7)	1 (6.7)	25 (75.8)	23 (69.7)	2 (6.0)
Nausea	12 (80.0)	12 (80.0)	0 (0.0)	19 (57.6)	19 (57.6)	0 (0.0)

TACE: Transcatheter arterial chemoembolization.

Citation: Ye HH, Ye JZ, Xie ZB, Peng YC, Chen J, Ma L, Bai T, Chen JZ, Lu Z, Qin HG, Xiang BD, Li LQ. Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein. World J Gastroenterol 2016; 22(13): 3632-3643
URL: https://www.wjgnet.com/1007-9327/full/v22/i13/3632.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i13.3632

Ye HH, Ye JZ, Xie ZB, Peng YC, Chen J, Ma L, Bai T, Chen JZ, Lu Z, Qin HG, Xiang BD, Li LQ. Comprehensive treatments for hepatocellular carcinoma with tumor thrombus in major portal vein. World J Gastroenterol 2016; 22(13): 3632-3643 [PMID: 27053855 DOI: 10.3748/wjg.v22.i13.3632]

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