Copyright
©The Author(s) 2016.
World J Gastroenterol. Mar 28, 2016; 22(12): 3471-3485
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471
Table 4 Summary of changes in anaerobic fermentation in pancreatic ductal adenocarcinoma
| Glycolytic enzyme | Encoding gene | Change in PDAC | Implicated pathways | Known inhibitors | Inhibitor effect in PDAC |
| Lactate dehydrogenase | Oxamate | Inhibits PDAC growth | |||
| Lactate dehydrogenase A | 11p15.4 | Up | c-Myc; mTor | Aryl-substituted N-hydroxyindole-2-carboxylates; Everolimus (by blocking the mTor pathway[28]) | Inhibits PDAC growth |
| Lactate dehydrogenase B | 1p12.2-p12.1 | Up | |||
| Lactate dehydrogenase C | 11p15.1 | - |
- Citation: Chan AK, Bruce JI, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
- URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3471