Glucose metabolic phenotype of pancreatic cancer

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2016; 22(12): 3471-3485
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3471

Table 4 Summary of changes in anaerobic fermentation in pancreatic ductal adenocarcinoma

Glycolytic enzyme	Encoding gene	Change in PDAC	Implicated pathways	Known inhibitors	Inhibitor effect in PDAC
Lactate dehydrogenase				Oxamate	Inhibits PDAC growth
Lactate dehydrogenase A	11p15.4	Up	c-Myc; mTor	Aryl-substituted N-hydroxyindole-2-carboxylates; Everolimus (by blocking the mTor pathway[28])	Inhibits PDAC growth
Lactate dehydrogenase B	1p12.2-p12.1	Up
Lactate dehydrogenase C	11p15.1	-

PDAC: Pancreatic ductal adenocarcinoma.

Citation: Chan AK, Bruce JI, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3471.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3471

Chan AK, Bruce JI, Siriwardena AK. Glucose metabolic phenotype of pancreatic cancer. World J Gastroenterol 2016; 22(12): 3471-3485 [PMID: 27022229 DOI: 10.3748/wjg.v22.i12.3471]

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