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©The Author(s) 2016.
World J Gastroenterol. Mar 28, 2016; 22(12): 3363-3371
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363
Table 1 Body weight, vasopressin and serum sodium in baseline conditions in cirrhotic rats prior to receiving tolvaptan (3 mg/kg), tolvaptan (5 mg/kg) or vehicle
| 1 d | 2 d | 3 d | 4 d | 5 d | ||
| Body weight (g) | Vehicle | 486.7 ± 12.57 (5) | 492.1 ± 10.12 (5) | 472.8 ± 18.21 (5) | 475.2 ± 9.21 (5) | 482.8 ± 13.24 (5) |
| Tolvaptan (3 mg/kg) | 502.3 ± 11.91 (6) | 487.3 ± 12.43 (6) | 465.6 ± 16.59 (6) | 465.6 ± 13.24 (6) | 476.3 ± 16.00 (5) | |
| Tolvaptan (5 mg/kg) | 493.4 ± 16.34 (6) | 485.2 ± 20.21 (6) | 490.1 ± 13.12 (6) | 472.1 ± 12.12 (6) | 490.1 ± 11.12 (6) | |
| Vasopressin(pg/L) | Vehicle | 13.25 ± 1.24 (5) | 14.15 ± 1.41 (5) | 15.44 ± 1.38 (5) | 14.99 ± 0.94 (5) | 13.05 ± 0.85 (5) |
| Tolvaptan (3 mg/kg) | 15.29 ± 0.93 (6) | 13.37 ± 1.22 (6) | 16.87 ± 0.73 (6) | 15.16 ± 1.17 (6) | 14.33 ± 0.99 (5) | |
| Tolvaptan (5 mg/kg) | 14.85 ± 1.39 (6) | 14.23 ± 0.81 (6) | 15.12 ± 1.21 (6) | 13.21 ± 1.21 (6) | 15.23 ± 0.81 (6) | |
| Serum sodium (mol/L) | Vehicle | 141.2 ± 1.31 (5) | 141.2 ± 1.11 (5) | 139.2 ± 0.75 (5) | 140.1 ± 0.92 (5) | 140.2 ± 1.31 (5) |
| Tolvaptan (3 mg/kg) | 139.2 ± 1.27 (6) | 141.3 ± 1.20 (6) | 138.2 ± 1.85 (6) | 140.1 ± 1.23 (6) | 138.2 ± 1.87 (5) | |
| Tolvaptan (5 mg/kg) | 141.2 ± 1.21 (6) | 140.9 ± 1.12 (6) | 142.2 ± 1.22 (6) | 138.1 ± 2.21 (6) | 139.1 ± 1.55 (6) |
- Citation: Chen C, Chen RP, Lin HH, Zhang WY, Huang XL, Huang ZM. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol 2016; 22(12): 3363-3371
- URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3363.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3363