Auphen and dibutyryl cAMP suppress growth of hepatocellular carcinoma by regulating expression of aquaporins 3 and 9 in vivo

Table 3 Correlation of AQP3 and AQP9 expression levels (low and high) to clinico-pathological data

Factors	AQP3		OR (95%CI)	P value	AQP9		OR (95%CI)	P value
	Low	High			Low	High
Gender
Male	4	19	0.526 (0.074-3.748)	0.603	16	1	7.111 (0.686-73.76)	0.138
Female	2	5			9	4
Age (yr)
< 50	1	4	1.000 (0.091-11.03)	1.000	3	2	0.205 (0.024-1.771)	0.183
> 50	5	20			22	3
Tumor size (cm)
< 5	3	5	3.800 (0.580-24.90)	0.300	6	2	0.474 (0.063-3.540)	0.589
> 5	3	19			19	3
Serum HBsAg
Positive	5	19	1.316 (0.124-13.98)	1.000	21	3	1.185 (0.166-8.475)	1.000
Negative	1	5			4	2
Serum AFP (ng/mL)
< 25	3	2	11.00 (1.271-95.23)	0.041	4	0	2.302 (0.107-49.54)	1.000
> 25	3	22			21	5
Cirrhosis
Presence	6	21	2.116 (0.096-46.56)	1.000	11	2	6.000 (0.780-46.17)	0.102
Absence	0	3			14	3
UICC stage
I + II	4	4	10.00 (1.341-74.55)	0.029	2	4	0.022 (0.002-0.300)	0.003
III + IV	2	20			23	1
Metastasis/recurrence
Yes	1	17	0.082 (0.008-0.839)	0.026	17	1	12.67 (1.177-136.4)	0.031
No	5	7			8	4
Edmondson grade
Low (I/II)	3	3	14.00 (1.741-112.6)	0.016	7	4	0.097 (0.009-1.029)	0.047
High (III/IV)	3	21			18	1