Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype

Table 4 Hepatitis delta virus serological profiles of patients

	HDV markers					HCV markers
			Serum HDV-RNA			Serum HCV-RNA
	Genotype	Anti-HD IgM	Status1	Log10 (copies/mL) (range)	VC	Anti-HCV	HCV-RNA
Pat #1	Und	Negative	Positive	5.90 ± 0.31 (5.53-6.11)	0.05	Negative	NA
Pat #2	A	Negative	Positive	5.69 ± 0.05 (5.64-5.72)	0.01	Negative	NA
Pat #3	E	Negative	Positive	5.11 ± 0.12 (5.02-5.20)	0.02	Negative	NA
Pat #4	A	Negative	Positive	4.38 ± 1.64 (2.60-5.84)	0.37	Negative	NA
Pat #5	A	Negative	Positive	6.47 ± 0.64 (5.70-7.18)	0.10	Negative	NA
Pat #6	D	Positive	Positive	4.55 ± 2.26 (1.08-5.75)	0.50	Negative	NA
Pat #7	E	Positive	Positive	4.01 ± 0.31 (3.57-4.43)	0.08	Negative	NA
Pat #8	D	Positive	Positive	4.13 ± 0.35 (3.89-4.38)	0.08	Negative	NA
Pat #9	A	Positive	Fluctuating	2.14 ± 0.99 (1.00-3.31)	0.46	Negative	NA
Pat #10	D	Positive	Fluctuating	4.07 ± 1.72 (1.00-5.07)	0.42	Negative	NA
Pat #11	A	Negative	Positive	5.47 ± 1.33 (4.53-5.47)	0.24	Negative	NA
Pat #12	D	Positive	Positive	4.76 ± 1.46 (1.70-6.22)	0.31	Negative	NA
Pat #13	A	Positive	Positive	4.53 ± 0.16 (4.41-4.64)	0.04	Negative	NA
Pat #14	D	Negative	Fluctuating	3.08 ± 2.95 (1.00-5.17)	0.96	Positive	Negative
Pat #15	D	Negative	Negative	NA	NA	Positive	Negative
Pat #16	E	Positive	Positive	6.26 ± 0.74 (5.74-6.78)	0.12	Negative	NA

¹Evolution of HDV-RNA during follow-up. Fluctuating is defined as a patient with alternating positive and negative samples. HDV genotype was I in the 16 samples analyzed. The number of patients with HCV infection was too low to perform statistical analysis. Und: undetermined genotype due to HBV-DNA negativity. VC: Variation coefficient; NA: Not applicable; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HDV: Hepatitis delta virus.