Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents

Figure 2 Mechanisms of action of green tea catechins, branched-chain amino acids, and acyclic retinoid in the inhibition of obesity-related liver carcinogenesis. HCC: Hepatocellular carcinoma; GTCs: Green tea catechins; BCAA: Branched-chain amino acid; ACR: Acyclic retinoid; TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6; IL-1β: Interleukin-1β; IGF-1: Insulin-like growth factor-1; IGF-1R: Insulin-like growth factor-1 receptor; IGFBP-3: IGF-binding protein-3; Stat3: Signal transducer and activator of transcription-3; Erk-1/2: Extracellular signal-regulated kinase-1/2; GSK-3β: Glycogen synthase kinase-3β; AMPK: AMP-activated kinase.