Impact of high glucose on metastasis of colon cancer cells

Figure 8 Effect of glucose on matrix metalloproteinase-9 and signal transducer and activator of transcription 3 expression. The expression of both matrix metalloproteinase-9 (MMP-9) (A, B) and n-signal transducer and activator of transcription 3 (STAT3) (A, C) proteins were dose-dependently and significantly higher than in the C (control) group. In the M30 group (treated with 30 mmol/L of mannitol), neither MMP-9 nor n-STAT3 expression was significantly higher than in the C (control) group. ^aP < 0.05 vs the control group; ^cP > 0.05 vs the control group. n = 6 per group. C: Control; 0 mmol/L; M30: Mannitol; 30 mmol/L.