Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing

Table 4 Genes downregulated by MYC in PICM-19-CSCs

Gene ID	Gene abbreviation	Function	log2 ratio
ASPN	Asporin	Extracellular matrix	8.20
IGF1	Insulin-like growth factor 1	Cell growth	7.44
OGN	Osteoglycin	Metabolism	6.52
GPM6B	Glycoprotein M6B	Membrane trafficking, cell-to-cell communication	6.23
ISLR	Immunoglobulin superfamily containing leucine-rich repeat	Unknown	6.19
ANGPT1	Angiopoietin 1	Angiogenesis	5.53
WDR66	WD repeat domain 66	EMT modulator	5.49
RSPO2	R-spondin 2 homolog	Wnt modulator	5.46
COL6A2	Collagen, type VI, alpha 2	Fibrosis	5.14
TNR	Tenascin R	Extracellular matrix	5.03
FAM5C	Family with sequence similarity 5, member C	Unknown	4.97
FIGF	c-Fos iduced growth factor	Angiogenesis	4.92
ADAM23	ADAM metallopeptidase domain 23	Metabolism	4.84
MAB21L2	Mab-21-like 2	Cell survival	4.83
PDE1A	Phosphodiesterase 1A	Metabolism, Apoptosis	4.83
CLMP	CXADR-like membrane protein	Cell adhesion	4.74
COL28A1	Collagen, type XXVIII, alpha 1	Fibrosis	4.74
GJA1	Gap junction protein, alpha 1	Oxidative stress	4.67
SELENBP1	Selenium binding protein 1	Tumor suppressor	4.58
CPED1	Cadherin-like and PC-esterase domain containing 1	Unknown	4.52
COL5A3	Collagen, type V, alpha 3	Fibrosis	4.51
ADAMTS2	ADAM metallopeptidase with thrombospondin typ1 motif 2	Metabolism	4.50
PDE8B	Phosphodiesterase 8B	Metabolism	4.47
SGCE	Sarcoglycan, epsilon	Cytoskeleton	4.42
GDPD2	Glycerophosphodiester phosphodiesterase domain containing 2	Cell growth	4.00